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Biochemistry Graduate Student Receives Spring 2026 Paper of the Season Award

Erin HammondsThe MCW Graduate Studies Committee awards committee has selected Erin Hammonds, graduate student in Dr. Emma Morrison's lab in the Department of Biochemistry, as the recipient of their Spring 2026 Paper of the Season Award. The paper, “Histone H3 Tail Charge Patterns Govern Nucleosome Condensate Formation and Dynamics", was published earlier this year in Nucleic Acids Research.

This study examines how nucleosomes (basic units of chromatin) form distinct “droplet-like” environments in the nucleus through phase separation. The researchers focused on the histone H3 tail and showed that changing its charge pattern affects how nucleosomes separate and form condensates, including their thickness (viscosity) and stability. They found that different regions of the H3 tail influence these properties in distinct ways. Even within these condensates, the H3 tails remain flexible, and their movement is linked to how fluid or solid the condensate is. Overall, the results show that the specific arrangement and type of charged residues in the H3 tail play a key role in controlling chromatin organization, supporting the idea that histone properties help shape nuclear structure and function.

This award program grants four awards per year (one during each season). Congratulations Erin!